| 957847022 | XP_014673988 | PDGF-B | PREDICTED: platelet-derived growth factor subunit A-like [Priapulus caudatus] | PDGF-A | blastp | alignment |
T-COFFEE, Version_11.00.8cbe486 (2014-08-12 22:05:29 - Revision 8cbe486 - Build 477)
Cedric Notredame
CPU TIME:0 sec.
SCORE=888
*
BAD AVG GOOD
*
XP_014673988.1 : 85
VEGF-C : 90
VEGF-D : 87
VEGF-A206 : 90
VEGF-A165 : 92
VEGF-A121 : 92
VEGF-B186 : 90
VEGF-B167 : 90
PlGF-1 : 92
VEGF-F : 91
PDGF-A : 85
PDGF-B : 80
PDGF-C : 87
PDGF-D : 82
cons : 88
XP_014673988.1 ------------------------------------
VEGF-C ------------------------------------
VEGF-D ------------------------------------
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 -MPV--------------------------------
VEGF-F ------------------------------------
PDGF-A MRTLACLLLLGCGYL---------------------
PDGF-B MNRCWALFLSLCCYL---------------------
PDGF-C --MSLFGLLLLTSALAGQRQGTQAESNLSSKFQFSS
PDGF-D MHRLIFVYTLICANFCSCRDTSATPQSASIKALRNA
cons
XP_014673988.1 ------------------------------------
VEGF-C ------------------------------------
VEGF-D ------------------------------------
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A ------------------------------------
PDGF-B ------------------------------------
PDGF-C N---KEQNGVQDP-QHERIITVSTNGSIHSPRFPHT
PDGF-D NLRRDESNHLTDLYRRDETIQVKGNGYVQSPRFPNS
cons
XP_014673988.1 ------------------------------------
VEGF-C ------------------------------------
VEGF-D ------------------------------------
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A ------------------------------------
PDGF-B ------------------------------------
PDGF-C YPRNTVLVWRLVAVEENVWIQLTFDERFGLEDPEDD
PDGF-D YPRNLLLTWRLHS-QENTRIQLVFDNQFGLEEAEND
cons
XP_014673988.1 ------------------------------------
VEGF-C ------------------------------------
VEGF-D ------------------------------------
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A ------------------------------------
PDGF-B ------------------------------------
PDGF-C ICKYDFVEVEEPSDGTIL--GRWCGSGTVPGKQISK
PDGF-D ICRYDFVEVEDISETSTIIRGRWCGHKEVPPRIKSR
cons
XP_014673988.1 ------------------------------------
VEGF-C --------MHLLGFFSVACSLLAAALLPGPREAPAA
VEGF-D --------MYREWVVVNVFMMLYVQLVQGS------
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A ------------------------------------
PDGF-B ------------------------------------
PDGF-C GNQIRIRFVSDEYFPSEPGFCIHYNIVMPQFTEA--
PDGF-D TNQIKITFKSDDYFVAKPGFKIYYSLLEDFQPAAAS
cons
XP_014673988.1 ---------------------------------MKI
VEGF-C AAAFESG---LDLSDAEPDAGEATAYAS-KDLEEQL
VEGF-D -------------SNEHGPVKRSSQSTL-ERSEQQI
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A -----------------AHVLAEEAEIP-REVIERL
PDGF-B -----------------RLVSAEGDPIP-EELYEML
PDGF-C ----------------VSPSVLPPSALPLDLLNNAI
PDGF-D ETNWESVTSSISGVSYNSPS-VTDPTLIADALDKKI
cons
XP_014673988.1 P---TSLLIRLSSVQTPED----FINSFVVGAPDRI
VEGF-C R--SVSSVDELMTVLYPEY-WKMYKCQLRKGGWQ-H
VEGF-D R--AASSLEELLRITHSED-WKLWRCRLRLKSFT-S
VEGF-A206 ----MNFLLSWVHWSLALL-LYLHHAKWSQAAPM-A
VEGF-A165 ----MNFLLSWVHWSLALL-LYLHHAKWSQAAPM-A
VEGF-A121 ----MNFLLSWVHWSLALL-LYLHHAKWSQAAPM-A
VEGF-B186 ------MSPLLRRLLLAAL-LQLAPAQAPVSQPD-A
VEGF-B167 ------MSPLLRRLLLAAL-LQLAPAQAPVSQPD-A
PlGF-1 ----MRLFPCFLQLLAGLA-LPAVPPQWALS-----
VEGF-F ----------MAAYLLAVA-ILFCIQGWPSGTVQ-G
PDGF-A ARSQIHSIRDLQRLLEIDSVGSEDSLDTSLRAHG-V
PDGF-B SDHSIRSFDDLQRLLHGDP-GEEDGAELDLNMTR-S
PDGF-C T--AFSTLEDLIRYLEPER-WQLDLEDLYRPTWQ-L
PDGF-D A--EFDTVEDLLKYFNPES-WQEDLENMYLDTPR-Y
cons
XP_014673988.1 RTD---S--S----SRK------ENV---PGL---Y
VEGF-C --NREQA------NLNS---R---TEETIKFAAAHY
VEGF-D --M----------DSRS---A---SHRSTRFAATFY
VEGF-A206 ------E--G----GGQ------NHHEVVKFM----
VEGF-A165 ------E--G----GGQ------NHHEVVKFM----
VEGF-A121 ------E--G----GGQ------NHHEVVKFM----
VEGF-B186 ------P--G----HQR---------KVVSWI----
VEGF-B167 ------P--G----HQR---------KVVSWI----
PlGF-1 ------A--G----NGS------SEVEVVPFQ----
VEGF-F --------------------------QVRPFL----
PDGF-A HATKHVPEKRPLPIRRK------RSI----------
PDGF-B HSGGELESLA----RGR------RSLGSLTIA----
PDGF-C ------L--G----KAFVFGRKSRVVDLNLLT----
PDGF-D ------R--G----RSY--HDRKSKVDLDRLN----
cons
XP_014673988.1 ED-------KIATFATCQVRPTIVDVPV--PT--NA
VEGF-C NTEILKSIDNEWRKTQCMPREVCIDVGKEFGV--AT
VEGF-D DIETLKVIDEEWQRTQCSPRETCVEVASELGK--ST
VEGF-A206 ---------DVYQRSYCHPIETLVDIFQEYPD--EI
VEGF-A165 ---------DVYQRSYCHPIETLVDIFQEYPD--EI
VEGF-A121 ---------DVYQRSYCHPIETLVDIFQEYPD--EI
VEGF-B186 ---------DVYTRATCQPREVVVPLTVELMG--TV
VEGF-B167 ---------DVYTRATCQPREVVVPLTVELMG--TV
PlGF-1 ---------EVWGRSYCRALERLVDVVSEYPS--EV
VEGF-F ---------EVHERSACQARETLVPILQEYPD--EI
PDGF-A ---------EEAVPAVCKTRTVIYEIPRSQVDPTSA
PDGF-B ---------EPAMIAECKTRTEVFEISRRLIDRTNA
PDGF-C ---------EEVRLYSCTPRNFSVSIREEL-K--RT
PDGF-D ---------DDAKRYSCTPRNYSVNIREEL-K--LA
cons . * :
XP_014673988.1 AELRWPSCVEVNRCRGCCSDY-MACNSTGVEIVYK-
VEGF-C NTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSK-
VEGF-D NTFFKPPCVNVFRCGGCCNEESLICMNTSTSYISK-
VEGF-A206 EYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITM-
VEGF-A165 EYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITM-
VEGF-A121 EYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITM-
VEGF-B186 AKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRM-
VEGF-B167 AKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRM-
PlGF-1 EHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTM-
VEGF-F SDIFRPSCVAVLRCSGCCTDESLKCTPVGKHTVDL-
PDGF-A NFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVK
PDGF-B NFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQ
PDGF-C DTIFWPGCLLVKRCGGNCACCLHNCNECQCVPSKVT
PDGF-D NVVFFPRCLLVQRCGGNCGCGTVNWRSCTCNSGKTV
cons * *: : ** * *
XP_014673988.1 ----KVYRVRY---EGANSEYFTYVGEEHVPIETHK
VEGF-C ----TLFEITV---PL-------SQGPKPVTISFAN
VEGF-D ----QLFEISV---PL-------TSVPELVPVKVAN
VEGF-A206 ----QIMRIKP------------HQGQHIGEMSFLQ
VEGF-A165 ----QIMRIKP------------HQGQHIGEMSFLQ
VEGF-A121 ----QIMRIKP------------HQGQHIGEMSFLQ
VEGF-B186 ----QILMIR-------------YPSSQLGEMSLEE
VEGF-B167 ----QILMIR-------------YPSSQLGEMSLEE
PlGF-1 ----QLLKIRS------------GDRPSYVELTFSQ
VEGF-F ----QIMRVNP----------R-TQSSKMEVMKFTE
PDGF-A VAKVEYVRKKP--------------KLKEVQVRLEE
PDGF-B VRKIEIVRKKP--------------IFKKATVTLED
PDGF-C KKYHEVLQLRP---KT---GVR-GLHKSLTDVALEH
PDGF-D KKYHEVLQFEPGHIKR---RGR-AKTMALVDIQLDH
cons : .
XP_014673988.1 QNSCVCACKIPA--SECG-----------PN-----
VEGF-C HTSCRCMSKLDVYRQVHS--II-------RR-----
VEGF-D HTGCKCLPTAP--RHPYS--II-------RR-----
VEGF-A206 HNKCECRPKKDR--ARQEKKSVRGKGKGQKRKRKKS
VEGF-A165 HNKCECRPKKDR--ARQE------------------
VEGF-A121 HNKCECRPKKDR--ARQE------------------
VEGF-B186 HSQCECRPKKKD--SAVK------------------
VEGF-B167 HSQCECRPKKKD--SAVK------------------
PlGF-1 HVRCECRPLREK--MKPE-----------RR-----
VEGF-F HTACECRPRRKQ--GEPD------------------
PDGF-A HLECACATTSL-N-PDYR------------------
PDGF-B HLACKCETVAAAR-PVTR------------------
PDGF-C HEECDCVCRGST--GG--------------------
PDGF-D HERCDCICSSRP--PR--------------------
cons : * *
XP_014673988.1 -----QIYEDCQCK-----------CVNG---NEAS
VEGF-C -----SLPA---------------------------
VEGF-D -----SI-----------------------------
VEGF-A206 RYKSWSVYVGARCCLMPWSLPGPHPCGPC---SERR
VEGF-A165 -----------------------NPCGPC---SERR
VEGF-A121 -K----------------------------------
VEGF-B186 -------------------PD------RAA---TPH
VEGF-B167 -------------------PDSPRP--LCPRCTQHH
PlGF-1 -----------------------RPKGRG---KRRR
VEGF-F ----------------------------GPKE----
PDGF-A -------------------------EEDT---GRPR
PDGF-B -------------------------SPGG---SQEQ
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_014673988.1 SCR---YPHE---WNKSL-CQCRCPVIT---GCATG
VEGF-C -----TLPQ---------C-QAANKTCP------TN
VEGF-D -----QIPEE----DR--C-SHSKKLCP------ID
VEGF-A206 KHLFVQDPQT---------CKCSCKNTD-SRCKARQ
VEGF-A165 KHLFVQDPQT---------CKCSCKNTD-SRCKARQ
VEGF-A121 ------------------------------------
VEGF-B186 HR---PQPRSVPGWDSAPGAPSPADITHPTPAPGPS
VEGF-B167 QR---PD------PRT---CRCRCRRRSFLRCQGRG
PlGF-1 EK---QRPTD---------C----------------
VEGF-F ------KPRR-GG------VRAKFPFV---------
PDGF-A ES---GKKRK--------R-KRLKPT----------
PDGF-B RA---KTPQT--------RVTI-RTVRVRRPPKGKH
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_014673988.1 QVFNHNTCSCDVDPN---AAMTAGD-----------
VEGF-C YMWNNHICRCLAQEDFMFSSDAGDDSTDGFHDICGP
VEGF-D MLWDSNKCKCVLQEE---NPLAGTEDHSHLQE----
VEGF-A206 LELNERTCRCDKPRR---------------------
VEGF-A165 LELNERTCRCDKPRR---------------------
VEGF-A121 ---------CDKPRR---------------------
VEGF-B186 AHAAPSTTSALTPGPAAAAADAAASSVAKGGA----
VEGF-B167 LELNPDTCRCRKLRR---------------------
PlGF-1 -----HLCGDAVPRR---------------------
VEGF-F ------------------------------------
PDGF-A ------------------------------------
PDGF-B RKFKHTHDKTALKETLGA------------------
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_014673988.1 ------------------------------------
VEGF-C NKELDEETCQCVCRAGLRPASCGPHKELDRNSCQCV
VEGF-D ------------------PALCGPHMM---------
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A ------------------------------------
PDGF-B ------------------------------------
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_014673988.1 ------------------------------------
VEGF-C CKNKLFPSQCGANREFDENTCQCVCKRTCPRNQPLN
VEGF-D ---------------FDEDRCECVCKTPCPKDLIQH
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A ------------------------------------
PDGF-B ------------------------------------
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_014673988.1 ------------------------------------
VEGF-C PGKCAC-ECTESPQKCLLKGKKFHHQTCSC------
VEGF-D PKNCSCFECKESLETCCQKHKLFHPDTCSCEDRCPF
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A ------------------------------------
PDGF-B ------------------------------------
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_014673988.1 ------DTALFSVFSPGT------------------
VEGF-C YRRPCTNRQKACEPGFSYSEEVCRCV-PSYWKRPQM
VEGF-D HTRPCASGKTACAKHCRFPKEKRAAQGPHSRKNP--
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A ------------------------------------
PDGF-B ------------------------------------
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_014673988.1 -
VEGF-C S
VEGF-D -
VEGF-A206 -
VEGF-A165 -
VEGF-A121 -
VEGF-B186 -
VEGF-B167 -
PlGF-1 -
VEGF-F -
PDGF-A -
PDGF-B -
PDGF-C -
PDGF-D -
cons