| 198416765 | XP_002128012 | PDGF-B | vascular endothelial growth factor A-A-like [Ciona intestinalis] | None | blastp | alignment |
T-COFFEE, Version_11.00.8cbe486 (2014-08-12 22:05:29 - Revision 8cbe486 - Build 477)
Cedric Notredame
CPU TIME:0 sec.
SCORE=662
*
BAD AVG GOOD
*
XP_002128012.1 : 57
VEGF-C : 65
VEGF-D : 66
VEGF-A206 : 73
VEGF-A165 : 74
VEGF-A121 : 77
VEGF-B186 : 75
VEGF-B167 : 73
PlGF-1 : 67
VEGF-F : 73
PDGF-A : 64
PDGF-B : 64
PDGF-C : 60
PDGF-D : 49
cons : 66
XP_002128012.1 MHQDL-RVK-SPQRFSIQSRC-T--S----------
VEGF-C ---MHLL-G-FFSVACSLLAAALLPGP--REAPAAA
VEGF-D ---MYRE-W-VVVNVFMMLYVQLVQGSSNE------
VEGF-A206 ---MNFL-L-SW------------------------
VEGF-A165 ---MNFL-L-SW------------------------
VEGF-A121 ---MNFL-L-SW------------------------
VEGF-B186 ---MSPL-L-RR------------------------
VEGF-B167 ---MSPL-L-RR------------------------
PlGF-1 ----MPV-MRLF------------------------
VEGF-F --MAAY--L-LA------------------------
PDGF-A ---MRTL-A-CLLLLGCGYLAHV--LA----EEA--
PDGF-B ---MNRC-W-ALFLSLCCYLRLV--SA----EGD--
PDGF-C ---M--S-L-FGLLLLTSALAGQ--RQ----GTQAE
PDGF-D ---MH-RLI-FVYTLICANFCSC--RD----TSATP
cons
XP_002128012.1 ------------------------------------
VEGF-C AAFESGL--------DLSDAEPDAGEATAYASKDLE
VEGF-D --------------------HGPVKRSSQSTLERSE
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A ------------------------EIPREVIERLA-
PDGF-B ------------------------PIPEELYEMLS-
PDGF-C SNLSSKFQFSSNK---EQNGVQDPQ-HERIITVST-
PDGF-D QSASIKALRNANLRRDESNHLTDLYRRDETIQVKG-
cons
XP_002128012.1 ---------KA-------------------------
VEGF-C EQLRSVSSVDEL----MTVLYP--------------
VEGF-D QQIRAASSLEEL----LRITHS--------------
VEGF-A206 -----VHWSLA----LLLYLHH--------------
VEGF-A165 -----VHWSLA----LLLYLHH--------------
VEGF-A121 -----VHWSLA----LLLYLHH--------------
VEGF-B186 -----L--LLAA----LLQLAP--------------
VEGF-B167 -----L--LLAA----LLQLAP--------------
PlGF-1 -----PC-FLQLLAGLALPAVP--------------
VEGF-F -----V--AILF----CIQG----------------
PDGF-A --RSQ-------------------IHSIRDLQR---
PDGF-B --DHS-------------------IRSFDDLQR---
PDGF-C --NGSIHSPRFP----HTYPRNTVLVWRLVAVEENV
PDGF-D --NGYVQSPRFP----NSYPRNLLLTWRLHSQ-ENT
cons
XP_002128012.1 -----------TGDSQSD-----------ISSTALF
VEGF-C ------------------------------------
VEGF-D ------------------------------------
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A ------------------------------------
PDGF-B ------------------------------------
PDGF-C WIQLTFDERFGLEDPEDDICKYDFVEVEEPSDGT--
PDGF-D RIQLVFDNQFGLEEAENDICRYDFVEVEDISETSTI
cons
XP_002128012.1 LSKCF-ISGSLRHNSLRSRQN-------DKAFFY--
VEGF-C ------------------------------------
VEGF-D ------------------------------------
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A --------------LLEIDSV-------GSEDSL--
PDGF-B --------------LLHGD-P-------GEEDGA--
PDGF-C ILGRWCGSGT-VPGKQISKGNQIRIRFVSDEYFPSE
PDGF-D IRGRWCGHKE-VPPRIKSRTNQIKITFKSDDYFVAK
cons
XP_002128012.1 -----MFAIVTGLL-LC-------------------
VEGF-C ------------------------------------
VEGF-D ------------------------------------
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A ------------------------------------
PDGF-B ------------------------------------
PDGF-C PGFCIHYNI----VMPQF-------------TEAVS
PDGF-D PGFKIYYSL----L-EDFQPAAASETNWESVTSSIS
cons
XP_002128012.1 ------------------------------------
VEGF-C ------------------------------------
VEGF-D ------------------------------------
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A --------------DT-SLRAHGVHATKHVP-----
PDGF-B --------------EL-DLNMTRSHSGGELE-----
PDGF-C ------PSVLPPSALPLDLLNNAITAFSTLEDLIRY
PDGF-D GVSYNSPSVTDPTLIA-DALDKKIAEFDTVEDLLKY
cons
XP_002128012.1 -----------TVVKGEFS-----------------
VEGF-C ---EYWKMYKCQLRKGGWQHNREQA--NLNSRTEET
VEGF-D ---EDWKLWRCRLRLKSFTSMD------SRSASHRS
VEGF-A206 ---AKW--------------------------SQAA
VEGF-A165 ---AKW--------------------------SQAA
VEGF-A121 ---AKW--------------------------SQAA
VEGF-B186 ---AQA--------------------------PVSQ
VEGF-B167 ---AQA--------------------------PVSQ
PlGF-1 ---PQ------------------------------W
VEGF-F -----W--------------------------PSGT
PDGF-A ------------------------------------
PDGF-B --------------SL-----------A--------
PDGF-C LEPERWQLDLEDLYRPTWQLLG-KAFVF--------
PDGF-D FNPESWQEDLENMYLDTPRYRG-RSYHD--------
cons
XP_002128012.1 -------HRIP-AYQD-VETALRSTKCAVREEIVDI
VEGF-C IKFA-AAHYNTEIL-KSIDNEWRKTQCMPREVCIDV
VEGF-D TRFA-ATFYDIETL-KVIDEEWQRTQCSPRETCVEV
VEGF-A206 PMAEGGGQNHH-EVVK-FMDVYQRSYCHPIETLVDI
VEGF-A165 PMAEGGGQNHH-EVVK-FMDVYQRSYCHPIETLVDI
VEGF-A121 PMAEGGGQNHH-EVVK-FMDVYQRSYCHPIETLVDI
VEGF-B186 P---DAPGHQR-KVVS-WIDVYTRATCQPREVVVPL
VEGF-B167 P---DAPGHQR-KVVS-WIDVYTRATCQPREVVVPL
PlGF-1 ALSAGNGSSEV-EVVP-FQEVWGRSYCRALERLVDV
VEGF-F --------VQG-QVRP-FLEVHERSACQARETLVPI
PDGF-A ----EKRPLPI-RRKR-SIEEAVPAVCKTRTVIYEI
PDGF-B ----R-GRRSL-GSLT-IAEPAMIAECKTRTEVFEI
PDGF-C ----GRKSRVV-DLNL-LTEEVRLYSCTPRNFSVSI
PDGF-D -----RKS-KV-DLDR-LNDDAKRYSCTPRNYSVNI
cons * :
XP_002128012.1 RDIHPHLPP--DVLLLPSCILIRKCSGCC-----QN
VEGF-C GKEFGVAT--NTFFK-PPCVSVYRCGGCC-----NS
VEGF-D ASELGKST--NTFFK-PPCVNVFRCGGCC-----NE
VEGF-A206 FQEYPDEI--EYIFK-PSCVPLMRCGGCC-----ND
VEGF-A165 FQEYPDEI--EYIFK-PSCVPLMRCGGCC-----ND
VEGF-A121 FQEYPDEI--EYIFK-PSCVPLMRCGGCC-----ND
VEGF-B186 TVELMGTV--AKQLV-PSCVTVQRCGGCC-----PD
VEGF-B167 TVELMGTV--AKQLV-PSCVTVQRCGGCC-----PD
PlGF-1 VSEYPSEV--EHMFS-PSCVSLLRCTGCC-----GD
VEGF-F LQEYPDEI--SDIFR-PSCVAVLRCSGCC-----TD
PDGF-A PRSQVDPTSANFLIW-PPCVEVKRCTGCC-----NT
PDGF-B SRRLIDRTNANFLVW-PPCVEVQRCSGCC-----NN
PDGF-C REEL-KRTD--TIFW-PGCLLVKRCGGNCACCLHNC
PDGF-D REEL-KLAN--VVFF-PRCLLVQRCGGNCGCGTVNW
cons . * *: : :* * *
XP_002128012.1 SRHVCKPTAIYVTRVEVSQQHV-------VR--RRL
VEGF-C EGLQCMNTSTSYLSKTLFEITV------PL--SQGP
VEGF-D ESLICMNTSTSYISKQLFEISV------PL--TSVP
VEGF-A206 EGLECVPTEESNITMQIMRIKP----------HQGQ
VEGF-A165 EGLECVPTEESNITMQIMRIKP----------HQGQ
VEGF-A121 EGLECVPTEESNITMQIMRIKP----------HQGQ
VEGF-B186 DGLECVPTGQHQVRMQILMIR-----------YPSS
VEGF-B167 DGLECVPTGQHQVRMQILMIR-----------YPSS
PlGF-1 ENLHCVPVETANVTMQLLKIRS-------G--DRPS
VEGF-F ESLKCTPVGKHTVDLQIMRVNP-------R--TQSS
PDGF-A SSVKCQPSRVHHRSVKVAKVEY------V-RKKPKL
PDGF-B RNVQCRPTQVQLRPVQVRKIEI------V-RKKPIF
PDGF-C NECQCVPSKVTKKYHEVLQLRP---KTGVRG--LHK
PDGF-D RSCTCNSGKTVKKYHEVLQFEPGHIKRRGRA--KTM
cons * :
XP_002128012.1 DYITLNFTHHDECECMSPIEPTCIPRACARHELWNK
VEGF-C KPVTISFANHTSCRCMSKLDVYRQVHSIIRRSLPAT
VEGF-D ELVPVKVANHTGCKCLP--TAPRHPYSIIRRSIQIP
VEGF-A206 HIGEMSFLQHNKCECRPK-----------KDRARQE
VEGF-A165 HIGEMSFLQHNKCECRPK-----------KDRARQE
VEGF-A121 HIGEMSFLQHNKCECRPK-----------KDRARQE
VEGF-B186 QLGEMSLEEHSQCECRPK-----------KKDSAVK
VEGF-B167 QLGEMSLEEHSQCECRPK-----------KKDSAVK
PlGF-1 YVELT-FSQHVRCECRPL-----------REKMKPE
VEGF-F KMEVMKFTEHTACECRPR-----------RKQGEPD
PDGF-A KEVQVRLEEHLECACATT-----------SLN----
PDGF-B KKATVTLEDHLACKCETV-----------AAARPVT
PDGF-C SLTDVALEHHEECDCVCRGSTGG-------------
PDGF-D ALVDIQLDHHERCDCICSSRPPR-------------
cons . .* * *
XP_002128012.1 EAC---------E---------------------CE
VEGF-C L----------PQCQAANKTCPTNYMWNNHI-CRCL
VEGF-D E-E--------DRCSHSKKLCPIDMLWDSNK-CKCV
VEGF-A206 K-KSVRGKGKGQKRKRKK---SRYKSWSVYVGARCC
VEGF-A165 ----------------------------N-------
VEGF-A121 ------------------------------------
VEGF-B186 P-D----------------------RAA--------
VEGF-B167 P-D----------------------SPR--------
PlGF-1 R-------------------------------RR--
VEGF-F G-P------------------------K--------
PDGF-A ------------------------------------
PDGF-B R-S---------------------------------
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_002128012.1 PRC----Q----------------------------
VEGF-C AQED-----FMFSSDAGDDSTDGFHDICGPNKELDE
VEGF-D LQEE--------NPLAGTEDHSH-------------
VEGF-A206 LMPWSLPGPHP----------------CGPCSER--
VEGF-A165 ----------P----------------CGPCSER--
VEGF-A121 -----------------------------K------
VEGF-B186 ---------------------------TP-------
VEGF-B167 ----------------------------P-------
PlGF-1 ----------P----------------KGRGKR---
VEGF-F ----------------------------E-------
PDGF-A ------------------------------------
PDGF-B ------------------------------------
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_002128012.1 ------------PQECGHGQVWNPRKCRCACSPCHP
VEGF-C ETCQCVCRAGLRPASCGPHKELDRNSCQCVCKNKLF
VEGF-D ---------LQEPALCGPHMMFD-------------
VEGF-A206 ------------------------------------
VEGF-A165 ------------------------------------
VEGF-A121 ------------------------------------
VEGF-B186 ------------------------------------
VEGF-B167 ------------------------------------
PlGF-1 ------------------------------------
VEGF-F ------------------------------------
PDGF-A --------------P-------------DYR-----
PDGF-B --------------P-------------GGS-----
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_002128012.1 NR----------------------LVHLRFDQNDVT
VEGF-C PSQCGANRE-----FDENTCQCVCKRTCPRNQPLNP
VEGF-D ----------------EDRCECVCKTPCPKDLIQHP
VEGF-A206 --RKHL-FVQDPQ-----------------TCKCSC
VEGF-A165 --RKHL-FVQDPQ-----------------TCKCSC
VEGF-A121 ------------------------------------
VEGF-B186 -----H-HRPQPRSVPGWDSAPGAPSPADITHPTPA
VEGF-B167 -------------LCPRCTQHHQRPDPR--TCRCRC
PlGF-1 ----RR-EKQRPT-----------------DCH-LC
VEGF-F -------------------------KPRRGGVRAKF
PDGF-A ------------------------EEDTGRPRES--
PDGF-B ------------------------QEQRAKTPQTRV
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_002128012.1 CICACRHELRHRTRCA-------KRRATFSQNSCAC
VEGF-C GKCAC-ECTESPQKCL-------LKGKKFHHQTCSC
VEGF-D KNCSCFECKESLETCC-------QKHKLFHPDTCSC
VEGF-A206 KN--------TDSRCK-------ARQLELNERTCRC
VEGF-A165 KN--------TDSRCK-------ARQLELNERTCRC
VEGF-A121 -----------------------------------C
VEGF-B186 PGP-------SAHAAPSTTSALTPGPAAAAADAAAS
VEGF-B167 RRR-------SFLRCQGRGLELNP-------DTCRC
PlGF-1 GD----------------------------------
VEGF-F PFV---------------------------------
PDGF-A ------------GKKR-------KRKR------LKP
PDGF-B TIRTVRVRRPPKGKHR-------KFKHTHDKTALKE
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_002128012.1 VGHFA----------------------RGK------
VEGF-C --YR------RPCTNRQKACEPGFSYSEEV-CRCVP
VEGF-D --EDRCPFHTRPCASGKTACAKHCRFPKEKRAA-QG
VEGF-A206 --DKPR----------------------R-------
VEGF-A165 --DKPR----------------------R-------
VEGF-A121 --DKPR----------------------R-------
VEGF-B186 --SVAK----------------------G-------
VEGF-B167 --RKLR----------------------R-------
PlGF-1 --AVPR----------------------R-------
VEGF-F ------------------------------------
PDGF-A --T---------------------------------
PDGF-B --TLG------------------------A------
PDGF-C ------------------------------------
PDGF-D ------------------------------------
cons
XP_002128012.1 ---------
VEGF-C SYWKRPQMS
VEGF-D PHSRKNP--
VEGF-A206 ---------
VEGF-A165 ---------
VEGF-A121 ---------
VEGF-B186 -------GA
VEGF-B167 ---------
PlGF-1 ---------
VEGF-F ---------
PDGF-A ---------
PDGF-B ---------
PDGF-C ---------
PDGF-D ---------
cons